Genetic architecture of subcortical brain structures in 38,851 individuals
نویسندگان
چکیده
منابع مشابه
Common genetic variants influence human subcortical brain structures
The highly complex structure of the human brain is strongly shaped by genetic influences. Subcortical brain regions form circuits with cortical areas to coordinate movement, learning, memory and motivation, and altered circuits can lead to abnormal behaviour anddisease. To investigate how commongenetic variants affect the structure of thesebrain regions, herewe conduct genome-wide association s...
متن کاملCommon genetic variants influence human subcortical brain structures
The highly complex structure of the human brain is strongly shaped by genetic influences1. Subcortical brain regions form circuits with cortical areas to coordinate movement2, learning, memory3 and motivation4, and altered circuits can lead to abnormal behaviour and disease2. To investigate how common genetic variants affect the structure of these brain regions, here we conduct genome-wide asso...
متن کاملDistinct Genetic Influences on Cortical and Subcortical Brain Structures
This study examined the heritability of brain grey matter structures in a subsample of older adult twins (93 MZ and 68 DZ twin pairs; mean age 70 years) from the Older Australian Twins Study. The heritability estimates of subcortical regions ranged from 0.41 (amygdala) to 0.73 (hippocampus), and of cortical regions, from 0.55 (parietal lobe) to 0.78 (frontal lobe). Corresponding structures in t...
متن کاملCommon genetic variants influence human subcortical brain structures
The highly complex structure of the human brain is strongly shaped by genetic influences. Subcortical brain regions form circuits with cortical areas to coordinate movement, learning, memory and motivation, and altered circuits can lead to abnormal behaviour anddisease. To investigate how commongenetic variants affect the structure of thesebrain regions, herewe conduct genome-wide association s...
متن کاملCommon genetic variants influence human subcortical brain structures
The highly complex structure of the human brain is strongly shaped by genetic influences. Subcortical brain regions form circuits with cortical areas to coordinate movement, learning, memory and motivation, and altered circuits can lead to abnormal behaviour anddisease. To investigate how commongenetic variants affect the structure of thesebrain regions, herewe conduct genome-wide association s...
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ژورنال
عنوان ژورنال: Nature Genetics
سال: 2019
ISSN: 1061-4036,1546-1718
DOI: 10.1038/s41588-019-0511-y